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Studies in hundreds of participants have found that higher blood levels of 1-methylnicotinamide (a marker related to NNMT activity) correlated with greater NNMT in adipose tissue, and were inversely related to insulin sensitivity

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Melanotan 1 has approved clinical applications in specific regulated indications, and researchers primarily study both compounds to better understand melanocortin receptor biology

That said, combining injectable and topical approaches creates a two-pronged strategy that addresses skin from both the inside out and the outside in